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Bansal, Monika
- Cerebroprotein Hydrolysate: Innovation in Neurodegenerative Disorders
Abstract Views :267 |
PDF Views:145
Authors
Nidhi Jain
1,
Shailesh Yadav
2,
Manoj Goyal
2,
Kiran Kumar Singal
3,
Parveen Gupta
3,
Monika Bansal
4
Affiliations
1 Pathology, MMIMSR Mullana, Ambala, Haryana, IN
2 Pharmacology, MMIMSR Mullana, Ambala, Haryana, IN
3 Medicine, MMIMSR Mullana, Ambala, Haryana, IN
4 Physiology, MMIMSR Mullana, Ambala, Haryana, IN
1 Pathology, MMIMSR Mullana, Ambala, Haryana, IN
2 Pharmacology, MMIMSR Mullana, Ambala, Haryana, IN
3 Medicine, MMIMSR Mullana, Ambala, Haryana, IN
4 Physiology, MMIMSR Mullana, Ambala, Haryana, IN
Source
International Journal of Medical and Dental Sciences, Vol 3, No 1 (2014), Pagination: 382-385Abstract
Stroke, traumatic brain injury and neurodegenerative disorders are one of the leading causes of death and disability in both developing and developed countries. A number of drugs including neurotrophic drugs are available for these disorders. Cerebroprotein hydrolysate is the latest one offering new hopes to patients suffering from these disorders. Its superiority is because of different actions which help in faster and more complete nerve repair and growth than other neurotrophic agents. It acts by multiple mechanisms viz.-regulation and improvement of the neuronal metabolism, modulation of the synaptic plasticity, promoting neuronal differentiation and protection against ischemic and neurotoxin lesion, reducing excitotoxic damage, blocking over activation of calcium dependent proteases, and scavenging free oxygen radicals. Till now no serious adversity has been reported.Keywords
Neurodegenarative Disorders, Cerebroprotein Hydrolysate, Neurotrophic Factors, Calpain.Full Text
References
- Larry BG, Robert A, Kyra B, Curt DF, Philip BG, George H et al. Primary Prevention of Ischemic Stroke. A Statement for Healthcare Professionals from the Stroke Council of the American Heart Association. Stroke 2001;32:28099.
- Injury Prevention & Control: Traumatic Brain Injury. Available from:http:// www.cdc.gov/traumaticbraininjury/. [last accessed on 30-nov-2011].
- Aziz-Sultan A, Baimeedi P, Benzel EC, Berger MS, Brandner S, Butowski N et al. Introduction to traumatic brain injury. In Samandouras G, editor. Traumatic brain injury: The Neurosurgeon's Handbook. 1st ed. Oxford: Oxford University Press; 2010.p.207-8.
- Sanjeev V Thomas. Addressing problems of dementia in India. Ann Indian Acad Neurol 2011;14:147.
- Introduction to neurogenesis. Available from http://www.neurogenesis .iord.org /.[Last accessed on 15th Oct. 2011].
- Available from: http://www.ceregene. com / neurotrophic.asp. [Last accessed on 30 Oct. 2011].
- Barrett KE, Barman SM, Boitano S, Brooks HL. Excitable Tissue: Nerve. In Ganong WF, editor. Physiology of nerve and muscle cells: Review of Medical Physiology. 23 rd ed. Lange: Mc Graw Hill; 2010.p.80.
- Gopalan T. Neurons: Key To Healing Of Brain Injuries Identified. August 24, 2010. Research News [online] Available from: http://www.medindia.net /news /Neurons-Key-To- Healing-Of-BrainInjuries-Identified-73058-2.htm. [Last accessed on Nov 28 2011].
- Long J, Wei GZ, Xu ZB, Feng YB. Injection of cerebroprotein hydrolysate vs Cerebrolysin in treating cerebrovascular diseases. Available from: http://en. cnki.com.cn/Article_en / CJFDTOTAL- XYYL606.002.htm. [Last accessed on March 07 2012].
- Sui CM, Kam WC, Jia-Hong L, Durairajan SSK, Liang-Feng L, Min L. Systematic Review on the Efficacy and Safety of Herbal Medicines for Vascular Dementia. Available from: http:// www. ncbi.nlm.nih.gov/pmc/articles/PMC325 0997. [Last accessed on March 07 2012].
- Honghui C, Tung YC, Li B, Iqbal K, Iqbal IG. Trophic factors counteract elevated EGF-2-induced inhibition of adult neurogenesis. Neurobiol Aging 2007 Aug;28(8):1148-62.
- Ruben JB, Dafang Wu, Manfred W. In Vivo upregulation of the blood–brain barrier GLUT1 glucose transporter by brain-derived peptides. Neuroscience Research 1999;34:217-224.
- Combining Ability Analysis for Horticultural Traits in French Marigold
Abstract Views :221 |
PDF Views:0
Authors
Affiliations
1 Department of Floriculture and Landscaping, Dr. Y. S. Parmar University, of Horticulture and Forestry, Nauni, Solan - 173230, Himachal Pradesh, IN
2 School of Agriculture, Lovely Professional University, Phagwara - 144411, Punjab, IN
1 Department of Floriculture and Landscaping, Dr. Y. S. Parmar University, of Horticulture and Forestry, Nauni, Solan - 173230, Himachal Pradesh, IN
2 School of Agriculture, Lovely Professional University, Phagwara - 144411, Punjab, IN
Source
Indian Journal of Science and Technology, Vol 8, No 23 (2015), Pagination:Abstract
Background/Objectives: French marigold (T. patula) hardy annual, about 30 cm tall, forming a bushy plants are grown as a loose flower and a garden flower. Four male sterile lines and 18 diverse pollinators as tester were used to produce 72 F1’s. These crosses and parents were evaluated for different ornamental characteristics. Methods/Statistical Analysis: These F1 hybrids along with 22 parental lines were evaluated during the summer (2009) and rainy season (2009) in Randomized Block Design. Highly significant variances for all the traits indicated the sufficient variability was observed in the parental material for all the characters under study. Findings: Among male sterile lines, ms8 (summer season) and ms9 (rainy season) proved good general combiners, while testers Spray Mix -1, Bonita Bolero and Safari Queen were the best general combiners for both the seasons. However, cross combinations viz. ms8 x Hero, ms10 x Hero, ms10 x Cupidon Yellow, ms8 x Double Dwarf Lemon was the best in terms of specific combining ability during the summer. Whereas, during winter the combinations viz. ms9 x French Bonita-3, ms10 x French Bonita-3, ms9 x Bonita Bolero, ms8 x Sunkist and ms9 x French Bonita-2 were best specific combiners. In both the seasons, the ration of σ2 GCA/σ2 SCA was less than unity for all the characters showing the preponderance of dominance variance. Applications: Marigold is especially used for festive occasions, marriages, religious ceremonies, social function and in landscape plans because its having a wide range of attractive colours, shape and size having good keeping quality. Now a days, marigold is used as a source of pigment for poultry feed. Caretonoids is used as poultry feed mix and food colourant. Lutin, is major component of Caretonoid is having therapeutic values. Marigold cultivation controls the nematode population in as well as mosquito repellant products are also being used. The mean sum of square for parentsvs crosses in this study for all the traits during summer and rainy season indicated the presence of heterosis. Thus it is obvious that heterotic effects represent an important resource in hybrid breeding of French marigold.Keywords
Combinig Ability, Carotene Content, GCA, Inbred Lines, Male Sterile Lines, Marigold, SCAFull Text
- Theoretical Study of Geometry of Quinazoline Derivatives and Their Antibacterial Activities
Abstract Views :195 |
PDF Views:0
Authors
Affiliations
1 Department of Chemistry, Punjabi University, Patiala 147002, Punjab, IN
1 Department of Chemistry, Punjabi University, Patiala 147002, Punjab, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 4 (2011), Pagination: 560-566Abstract
Quinazolines are a pharmacologically very attractive class of compounds. In the preliminary communication, 4- substituted phenyl-3,4,5,6-tetrahydrobenzo[h]quinazoline-2(1H)-thiones and their S-alkyl/aralkyl derivatives were synthesized. Through the Gaussian 03 studies, the expected stereochemistry of the synthesized compounds was checked. Also, the compounds were tested for antibacterial activities against Staphylococcus aureus, Pseudomonas fluorescence.
Keywords
Quinazolines, Gaussian Studies, Stereochemistry, Antibacterial Activities.
- Synthesis and Antimicrobial Activities of Thiazolo [3, 2-a] Pyrimidine Derivatives
Abstract Views :205 |
PDF Views:1
Authors
Affiliations
1 Department of Chemistry, Punjabi University, Patiala-147002 (Punjab), IN
1 Department of Chemistry, Punjabi University, Patiala-147002 (Punjab), IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 1 (2011), Pagination: 116-119Abstract
In the present study a novel thiazolo [3,2-a] pyrimidines were synthesized by one pot multicomponent cyclocondensation of 2-amino-4-phenyl thiazole, benzoyl acetone and various substituted aromatic aldehydes on solid support under microwave irradiations. The 2-amino-4-phenyl thiazole was synthesized from acetophenone. Some of the compounds were screened for anti-bacterial (Staphylococcus aureus, Staphylococcus aureus (MRSA), Staphylococcus pyogenes) and antifungal (Aspergillus niger, Neurospora crassa) activities by Agar Diffusion method.